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Phenytoin sodium

Phenytoin: Uses, Dosage, Side Effects, Warnings - Drugs

Phenytoin is an anti-epileptic drug, also called an anticonvulsant. Phenytoin works by slowing down impulses in the brain that cause seizures. Phenytoin is used to control seizures. It does not treat all types of seizures, and your doctor will determine if it is the right medicine for you Parenteral Phenytoing Sodium Injection is indicated for the treatment of generalized tonic-clonic status epilepticus, and prevention and treatment of seizures occurring during neurosurgery. intravenous phenytoin can also be substituted, as short-term use, for oral phenytoin

Phenytoin Sodium - FDA prescribing information, side

Phenytoin Sodium Oral: Uses, Side Effects, Interactions

  1. USES: Phenytoin is used to prevent and control seizures (also called an anticonvulsant or antiepileptic drug)
  2. Phenytoin is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cortex reducing post-tetanic potentiation at synapses. The reduction of potentiation prevents cortical seizure foci spreading to adjacent areas, stabilizing the threshold against hyperexcitability
  3. istration. The solution is in a vehicle containing 40% propylene glycol and 10% alcohol in water for injection, adjusted to pH 12 with sodium hydroxide
  4. Phenytoin Dose-Dependent Adverse Effects (aka indications of phenytoin toxicity) Nausea/vomiting (early) Nystagmus. Ataxia. CNS depression (including coma and possible respiratory failure) Pod 2: Phenytoin Protein Binding and Volume of Distribution (Vd) One of the reasons phenytoin is so difficult to predict is because it is highly protein bound

Phenytoin sodium is an antiepileptic drug. Phenytoin sodium is related to the barbiturates in chemical structure, but has a five-membered ring. The chemical name is sodium 5,5-diphenyl-2, 4-imidazolidinedione, having the following structural formula: Each Dilantin— 100 mg Extended Oral Capsule—contains 100 mg phenytoin sodium. Als Phenytoin sodium dissociates easily to regenerate phenytoin, even in weakly acidic solutions. Phenytoin may also be administered as the water-soluble prodrug fosphenytoin (molecular weight = 362.3) or its disodium salt (molecular weight = 406.2), which are converted to phenytoin by phosphatases in th Phenytoin injection is contraindicated in patients with sinus bradycardia, sino-atrial block, second or third degree AV block, and Adams-Stokes syndrome because of the effects of the drug on ventricular automaticity Phenytoin (FEN-ih-toe-in) is the generic name (non-brand name) of a widely used seizure medicine. Common brand names for this type of medicine include Dilantin, Phenytek, and Epanutin (in the UK), but it is also sold using the name phenytoin or phenytoin sodium The sodium salt form of phenytoin, a hydantoin derivate and non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin sodium promotes sodium efflux from neurons located in the motor cortex, thereby stabilizing the neuron and inhibiting synaptic transmission

dosage forms or salt forms (phenytoin sodium versus phenytoin base) and/or interchanging brands may also lead to changes in bioavailability - monitoring the phenytoin level during the period of changeover will also help to optimise the anticonvulsant efficacy Phenytoin (Dilantin, Phenytek) is a moderately priced drug used to control seizures in certain types of epilepsy. It is also used to prevent seizures during or after surgery. This drug is less popular than comparable drugs. It is available in brand and generic versions Understand the effects of alcohol: Alcohol intake may increase phenytoin serum levels, leading to phenytoin toxicity. Discontinue drug immediately if a measles-like skin rash or jaundice appears and notify physician. Be aware that influenza vaccine during phenytoin treatment may increase seizure activity Phenytoin is a commonly used medicine. It works by stabilising the electrical activity of your brain, which prevents the seizures from occurring Dilantin (phenytoin sodium injection, USP) is a ready-mixed solution of phenytoin sodium in a vehicle containing 40% propylene glycol and 10% alcohol in water for injection, adjusted to pH 12 with sodium hydroxide. Phenytoin sodium is related to the barbiturates in chemical structure, but has a five-membered ring. The chemical name is sodium 5.

Phenytoin Sodium Injection is formulated with the sodium salt of phenytoin. Because there is approximately an 8% increase in drug content with the free acid form over that of the sodium salt, dosage adjustments and serum level monitoring may be necessary when switching from a product formulated with the free acid to a product formulated with. Dilantin (phenytoin sodium) Full Prescription Information. Detailed Info on Signs, Symptoms, Causes, Treatments of Bipolar Disorder. back to: Psychiatric Medication Patient Information Index. APA Reference Staff, H. (2009, January 3). Dilantin (Phenytoin Sodium) Patient Information, HealthyPlace. Retrieved on 2021, May 4 from https://www. Phenytoin Sodium Flynn Hard Capsules are indicated for control of tonic- clonic seizures (grand mal epilepsy), partial seizures (focal including temporal lobe) or a combination of these, and for the prevention and treatment of seizures occurring during or following neurosurgery and/or severe head injury

Phenytoin Oral Suspension BP - GNH India - Exporter

Phenytoin Side Effects, Dosage, Uses, and Mor

Pentobarbital Sodium and Phenytoin Sodium is available in 100 mL multi-dose vials in package of one, NDC 13985-992-90. Manufactured by a nonsterilizing process. Store at controlled room.. Phenytoin sodium European Pharmacopoeia (EP) Reference Standard Synonym: 5,5-Diphenyl-2,4-imidazolidinedione, 5,5-Diphenylhydantoin sodium salt, Phenytoin CAS Number 630-93-3. Linear Formula C 15 H 11 N 2 O 2 Na . Molecular Weight 274.25 . MDL number MFCD00069674. PubChem Substance ID 329820086. NACRES NA.2 When a change in the dosage form or brand is prescribed, careful monitoring of phenytoin serum levels should be carried out by your doctor. Like other antiepileptic drugs, DILANTIN may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Before you take DILANTIN, tell your healthcare provider if you have or have. Only DILANTIN (extended phenytoin sodium capsules, USP) are recommended for once-a-day dosing. Inherent differences in dissolution characteristics and resultant absorption rates of phenytoin due to different manufacturing procedures and/or dosage forms preclude such recommendation for other phenytoin products. When a change in the dosage form. Phenytoin sodium (Dilantin) is an inactive voltage-gated sodium channel stabilizer. Find all the information about Phenytoin sodium (Dilantin) for cell signaling research

Phenytoin sodium may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques. These Secondary Standards are qualified as Certified Reference Materials In hyper excitable state, increase in sodium in cells leads to activation of Na K ATPase to bring back concentration to resting level. In patients of epilepsy, decrease in activity of Na K ATPase occurs, phenytoin causes increase in the enzyme so increase outflux of Na+ occurs, along with increased influx of K+ ions

Phenytoin - Wikipedi

Phenytoin sodium for injection was added to 250 ml of an intravenous fluid to give calculated initial concentrations of 0.40, 0.98, 2.38, and 4.55 mg/ml. The pH of each solution was determined before and after the addition of phenytoin Loading Dose: A loading dose of parenteral Phenytoin Sodium Injection should be injected slowly, not exceeding 50 mg per minute in adults and 1-3 mg/kg/min (or 50 mg per minute, whichever is slower) in pediatric patients phenytoin sodium = 1.5 mg fosphenytoin sodium. 2. Total body weight (TBW) is defined as the actual total mass of the patient in kilograms. Introduction. Fosphenytoin is a water soluble prodrug of phenytoin which is rapidly converted to phenytoin after intravenous (IV) or intramuscular (IM) administration. Fosphenytoi Phenytoin sodium, parenteral. Status epilepticus: 10-15 mg/kg by slow IV. For maintenance, 100 mg PO or IV q 6-8 hr. Higher doses may be required. Do not exceed an infusion rate of 50 mg/min. Follow each IV injection with an injection of sterile saline through the same needle or IV catheter to avoid local venous irritation by the alkaline. Agent: Sodium Bicarbonate (NaHCO3 8.4%) Rationale: Precipitation of phenytoin likely related to administration into an acidic solution (dextrose containing solution). Increasing the pH of the medium with sodium bicarbonate may allow for dissolution of the phenytoin precipitate and clearance of the catheter. Technique: 1

Interaction between a vaccine and a drug has been reported only with influenza vaccine and four drugs (aminopyrine, phenytoin sodium, theophylline, and warfarin sodium), and with BCG vaccine and theophylline. Some of these interactions still are unconfirmed. The underlying mechanism of the interacti The global Phenytoin sodium Market... May 05, 2021 (The Expresswire) -- Final Report will add the analysis of the impact of COVID-19 on this industry. MarketWatch Site Log Phenytoin sodium is an anti-epileptic drug, which belongs to the hydantoin family. Biochem/physiol Actions Reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na +, K +, and Ca 2+ channels. Analysis Note These products are for test and assay use only

PHENYTOIN SODIUM CAPSULES - ORAL (Dilantin) side effects

Phenytoin exerts its antiarrhythmic effects by normalizing sodium influx to Purkinje's fibers in patients with cardiac glycoside-induced arrhythmias. It's indicated for generalized tonic-clonic (grand mal) and partial seizures. Other actions: Inhibits excessive collagenase activity in patients with epidermolysis bullosa A: Dissolve about 300 mg of Phenytoin Sodium, accurately weighed, in about 50 mL of water in a separator. Add 10 mL of 3 N hydrochloric acid, and extract with three successive portions, measuring 100, 60, and 30 mL, respectively, of a 1 in 2 mixture of ether and chloroform Dilantin; Dilantin Infatabs; Phenytek; Phenytoin Infatabs Brand Names: Canada APO-Phenytoin Sodium; Dilantin; Dilantin Infatabs; Dilantin-125; Dilantin-30; NOVO-Phenytoin [DSC]; TARO-Phenytoin; Tremytoine Warning Injection: This drug may cause an abnormal heartbeat or low blood pressure if given too fast. Sometimes, this has been deadly Phenytoin (diphenylhydantoin; Dilantin) is a nonsedating anticonvulsant agent that is effective against generalized tonic‐clonic and partial complex seizures. It has also been used as an antidysrhythmic drug. Oral preparations contain either phenytoin acid or phenytoin sodium in prompt‐release, extended‐release, or suspension formulations Phenytoin 5/10 child's nurse if your child has any redness, burning, pain, swelling, blisters, skin sores, or leaking of fluid where the drug is going into your child's body

Phenytoin/Dilantin was first used for epi in the 1940s and the patent has long since expired. In the UK the drug is marketed as ''Epanutin'' rather than ''Dilantin'' and, according to the (2008) National Health Service's annual Prescription Cost Analysis (the official breakdown of NHS expenditure on drugs), a 100mg capsule cost about 3.3p, or. Structure, properties, spectra, suppliers and links for: phenytoin sodium, 630-93-3 : a crystalline anticonvulsant compound C15H12N2O2 used in the form of its sodium salt in the treatment of epilepsy — called also diphenylhydantoin Examples of phenytoin in a Sentence Recent Examples on the Web In the effluent from the Morgantown wastewater plant, the USGS team found high concentrations of three drugs in addition to phenytoin Capsules/injection= 92% phenytoin (sodium salt). Elixir/tabs=100% phenytoin. Equation used to estimate the dose required to increase current level to normal range if subtherapeutic: = [0.7 x IBW x (15 - current level) ] / 0.92* * (if capsules/injection used

Phenytoin sodium is an antiepileptic drug. Phenytoin sodium is related to the barbiturates in chemical structure, but has a five-membered ring. The chemical name is sodium 5,5-diphenyl-2, 4-imidazolidinedione, having the following structural formula Each 5ml of solution contains Phenytoin Sodium 250mg. Excipient (s) with known effect Each 5ml of solution also contains 404.25 mg of Ethanol, 2070 mg of propylene glycol and not more than 23mg of Sodium. For the full list of excipients, see section 6.1 Phenytoin sodium (Dilantin) is a sodium channel protein inhibitor. Catalog Num: A10722: CAS No. 630-93-3: Formula: C15H11N2NaO2: M. Wt: 274.25: Solubilit Phenytoin is classified as an antiarrhythmic and can cause SA and AV nodal blocks as well as dysrhythmias due to its effect on voltage-gated sodium channels. 3 Further, since phenytoin is poorly soluble, the parenteral form is administered with propylene glycol, which is a cardiac depressant. 3 The infusion rate of parenteral phenytoin should. Storage. Phenytoin sodium should be kept in a tightly closed container. Additional information. Phenytoin sodium is somewhat hygroscopic and on exposure to air gradually absorbs carbon dioxide. Requirements Definition. Phenytoin sodium contains not less than 98.5% and not more than 101.0% of C 15 H 11 N 2 NaO 2, calculated with reference to the.

Phenytoin bekerja dengan cara mengurangi aktivitas kelistrikan di otak yang berlebih, sehingga kejang bisa mereda. Merek dagang phenytoin: Curelepz, Decatona, Dilantin, Ikaphen, Kutoin, Phenitin, Phenytoin Sodium Apa Itu Phenytoin DILANTIN extended capsules and parenteral DILANTIN are formulated with the sodium salt of phenytoin. The free acid form of phenytoin is used in DILANTIN-125 Suspension and DILANTIN Infatabs Phenytoin sodium is an inactive voltage-gated sodium channel stabilizer.Target: Sodium ChannelPhenytoin sodium is an antiepileptic drug. It is useful to treat partial seizures and generalized tonic-clonic seizures but not primary generalized seizures such as absence seizures or myoclonic seizures Phenytoin binds preferentially to the inactive form of the sodium channel. Because it takes time for the bound drug to dissociate from the inactive channel, there is a time dependent block of the channel

Phenytoin Sodium Inj: Phenytoin belongs to the group of medications known as anti-epileptics. Phenytoin is used to manage and prevent certain types of seizures, as well as to prevent and treat seizures that occur during or following neurosurgery. It works on the brain to reduce the number and severity of seizures Name Phenytoin sodium Drug Entry Phenytoin. Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants. 12,6,8 Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as bipolar. Phenytoin induces hepatic metabolizing enzymes, which may enhance metabolism of vitamin D and decrease vitamin D levels, leading to vitamin D deficiency, hypocalcemia, and hypophosphatemia;.. Phenytoin sodium is the sodium salt of phenytoin. It is a white, scentless, somewhat hygroscopic crystalline powder. It is solvent in water and liquor. The medicine is additionally utilized to counteract seizures after brain surgery. The medication is in a category of solutions recognized as anticonvulsants View All Manufacturers & Suppliers of Phenytoin Sodium API with Drug Master Files (DMF), CEP/COS, Japanese DMFs, Written Confirmation (WC) details listed on PharmaCompass.co

Phenytoin sodium, 5,5-diphenyl-2,4-imidazolidinedione, 5,5-diphenylhydantoin,diphenyl-hydantoin sodium (Dilantin), has been used fordecades in the control of grand mal types of epilepticseizure. It is structurally analogous to the barbiturates butdoes not possess their extensive sedative properties. Thecompound is available as the sodium salt Phenytoin can speed up the removal of other medications from your body, which may affect how they work. Examples of affected drugs include atazanavir, some drugs to treat cancer (such as imatinib, irinotecan), cobicistat, corticosteroids (such as prednisone), doravirine, felodipine, quetiapine, quinidine, suvorexant, theophylline, vitamin D.

Revision Bulletin Official April 1, 2010 Phenytoin1 Extended Phenytoin Sodium Capsules Acceptance Table Number Stage Tested Acceptance Criteria » Extended Phenytoin Sodium Capsules contain notS 1 6 Each unit is within the range between Q less than 95.0 percent and not more than 105.0 percent − 15% and Q − 5%, is within the range of the labeled amount of phenytoin sodiumQ′ ± 10%, and is. Phenytoin is a sodium channel blocker, this is why you should never give it as an intravenous bolus. It would cause acute sodium channel blockade like a tricyclic antidepressant causing widening of the QRS with risk of dysrhythmias including VT. Specifically it suppresses membrane post-titanic potentiation and hyper excitability Intravenous phenytoin sodium produced moderate pain and burning at the infusion site, and phlebitis was still present in 7 of the 12 volunteers 5 days after the infusion. Fosphenytoin sodium: new drug to replace intravenous phenytoin sodium Phenytoin (Dilantin, Phenytek) is a moderately priced drug used to control seizures in certain types of epilepsy.It is also used to prevent seizures during or after surgery. This drug is less popular than comparable drugs. It is available in brand and generic versions

Storage: Phenytoin sodium should be kept in a tightly closed container. Additional information: Phenytoin sodium is somewhat hygroscopic and on exposure to air gradually absorbs carbon dioxide. Definition: Phenytoin sodium contains not less than 98.5% and not more than 101.0% of C15H11N2NaO2, calculated withreference to the dried substance Phenytoin sodium is used in the commercially available capsules (both extended and prompt) andthe injectable preparations. Phenytoin (base) is used in the oral tablets and suspensions. Each 100mg of phenytoin sodium contains 92 mg of the base. Storage, Stability, Compatibilit

Phenytoin sodium extended is used to treat certain types of seizures and to prevent seizures in surgery. Start saving up to 75% off the retail price of this medication when you print our free coupons and present them in your local pharmacy to get a discount Elephant specific information, if available, is in blue. Chemistry - A hydantoin-derivative, phenytoin sodium occurs as a white, hygroscopic powder which is freely soluble in water and warm propylene glycol, and soluble in alcohol.. Because phenytoin sodium slowly undergoes partial hydrolysis in aqueous solutions to phenytoin (base) with the resultant solution becoming turbid, the commercial.

A pharmaceutical composition is provided containing an admixture of phenytoin sodium and an erodible matrix which extends the release of the phenytoin sodium over about a two hour period. The erodible matrix comprises binder(s) and diluent(s) which control the release of drug from the pharmaceutical composition. The erodible matrix can further comprise an alkaline pH modifier phenytoin sodium extended Phenytoin is used to prevent and control seizures (also called an anticonvulsant or antiepileptic drug). It works by reducing the spread of seizure activity in the brain Phenytoin injection is an anticonvulsant medication that is used to treat a prolonged seizure (status epilepticus).Phenytoin injection is also used to prevent seizures during a surgery.. Phenytoin injection may also be used for purposes not listed in this medication guide

bioavailability & bioequivalence

Extended Phenytoin Sodium Capsules DEFINITION Extended Phenytoin Sodium Capsules contain NLT 95.0% and NMT 105.0% of the labeled amount of phenytoin sodium (C15H11N2NaO2). IDENTIFICATION Change to read: • A. INFRARED ABSORPTION—GENERAL á197ñ Sample: 300 mg of phenytoin sodium from the contents of Capsules in 50 mL of water in a separator. Phenytoin Sodium is an anti-epileptic medication (centrally acting anti-convulsant) that hyperpolarises the nerve membrane so that the potential threshold is increased and decreases the action potential peak thereby reducing clinical signs i.e. firing of the nerves is dampened. In addition, it can be used in dogs and cats as an antiarrhythmic phenytoin sodium or phenytoin, the active ingredients in Dilantin, or other hydantoin medicines or any of the ingredients listed at the end of this leaflet methylphenobarbitone or any other.. Phenytoin is an inactive voltage-gated sodium channel stabilizer.;Target: Sodium ChannelPhenytoin is an antiepileptic drug. It is useful to treat partial seizures and generalized tonic-clonic seizures but not primary generalized seizures such as absence seizures or myoclonic seizures

Status epilepticus

Phenytoin C15H12N2O2 - PubChe

Description What is Phenytoin Sodium? Phenytoin Sodium, Prompt injection is an anticonvulsant medication that is used to treat a prolonged seizure (status epilepticus). Phenytoin Sodium, Prompt injection is also used to prevent seizures during a surgery. Important Information. A Phenytoin Sodium, Prompt injection may cause life-threatening heart problems Phenytoin (Lepitoin; NSC 8722; Phenytek; Phenytoine; Sodanton; Zentropi) is an inactive voltage-gated sodium channel stabilizer. Find all the information about Phenytoin (Lepitoin) for cell signaling research Compare phenytoin sodium (dilantin) 100 mg prices from verified online pharmacies or local U.S. pharmacies. Print free coupons for phenytoin sodium, shop safely and save money on your prescription medication costs today

Dilantin (phenytoin) for Epilepsy: Uses, Dosage, Side

Phenytoin Sodium possesses anti-arrhythmic and muscle relaxant properties. It is widely used to treat a variety of seizures and works by reducing the spread of seizure activity in the brain. The chemical formula of the compound is C15H11N2NaO2 and the IUPAC name is sodium,5,5-diphenylimidazolidin-3-.. Dilantin (phenytoin) is one of the first anticonvulsant medications as it was developed in the early 1900s. Its major uses are for the prevention of seizures, particularly tonic-clonic seizures (that affect the entire brain) or partial seizures (seizures that affect only half of the brain or one area) Phenytoin sodium is the sodium salt of phenytoin, and it was synthesized in order to increase the solubility of the medication. Phenytoin itself has a water solubility of 0.032 g/L, which means you'd need around 31 L of water to dissolve a gram of phenytoin. 1 g of phenytoin sodium, on the other hand, can be dissolved in 66 mL of water

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The Complete (but Practical) Guide to Phenytoin Dosing

The Phenytoin (Dilantin) Correction for Albumin / Renal Failure corrects serum phenytoin level for renal failure and/or hypoalbuminemia. This is an unprecedented time. It is the dedication of healthcare workers that will lead us through this crisis Phenytoin is a voltage-gated, sodium channel blocker, stabilizing the inactive state of the sodium channel and prolonging the neuronal refractory period. Phenytoin acts on the sodium channels on both neuronal and cardiac tissue. In the central nervous system, it targets neurons with high-frequency activity (as observed in seizures), with the. PHENYTOIN SODIUM - chemical information, properties, structures, articles, patents and more chemical data Chem 216 S11 Notes - Dr. Masato Koreeda Date: May 10, 2011 Topic: _Experiment 5__ page 1 of 2. Experiment 5. Benzilic Acid Rearrangement: Preparation of Dilantin Anticonvulsant drugs: Epilepsy: one of the most common Dilantin Sodium (phenytoin)* neurologic disorders, affecting ca. 1% of Tegretol (carbazepine) the population No generic medication is available for Dilantin (Phenytoin Sodium

Phenytoin Sodium - NDC drug/product. NDCs and labelers of Phenytoin Sodium: NDC Trade Name Labeler Name; 50090-1480: PHENYTOIN SODIUM: A-S Medication Solutions: 50090-2903: PHENYTOIN SODIUM: A-S Medication Solutions: 50090-3499: Phenytoin Sodium: A-S Medication Solutions: 50090-3539: Phenytoin Sodium Phenytoin is a drug prescribed to treat or prevent the recurrence of certain types of seizures (see Epilepsy), including complex partial seizures (impaired consciousness that is preceded, accompanied, or followed by psychological symptoms) or generalized tonic-clonic seizures (involve abrupt loss of consciousness, respiratory arrest, muscle rigidity) Phenytoin is a medicine used to treat epilepsy. It can also be used to treat trigeminal neuralgia, a type of nerve pain that affects your face. Phenytoin is available on prescription. It comes as tablets that can be chewed or dissolved in water, capsules and a liquid that you swallow

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